Gemfibrozil and fenofibrate are prescribed for dyslipidemia. Most of dyslipidemic cases are seen in adults. In addition, little is known about the effects of chronic treatment with PPARα agonists on neuroinflammation. Therefore, we examined the influence of chronic treatment with PPARα agonists on neuroinflammation in adult mice. In the current study, we induced neuroinflammation by injecting LPS directly into the somatosensory cortex so that potential direct interactions between the systemically administered PPARα agonists and LPS were minimized. This model could also minimize the potential influence of LPS on peripheral organs.
