Chromosomes 6p21.2 and 6p21.32 belong to the chromosomal region of major histocompatibility complex, and have been previously linked to psychiatric disorders including schizophrenia6, 40 and bipolar affective disorder,41 as well as neurologic disease such as photosensitive epilepsy,42 late-onset Alzheimer disease43 and restless legs syndrome.44 In this study, we discovered novel suggestive associations of HLA-DRB1*01:01 and DRB1*04:04 with ASPD. Previous studies have reported the same alleles in association with schizophrenia,45, 46, 47 whereas other studies have not been able to replicate those findings48 and the link has remained controversial. In this study, additional analysis of coding polymorphisms suggested an independent role for Valine at position 11 on DRB1 that was tagged by one of the most significant GWAS hits in this study, rs2395163. The findings suggest that ASPD may share genetic risk factors in this locus with other psychiatric and neurological disorders.
