four loci (NEGR1, TMEM18, SH2B1 and MC4R) in six African-American cohorts that demonstrated consistent association with previous studies of adiposity in Europeans. These loci are all highly expressed in the brain (and several especially in the hypothalamus), consistent with an important role for central nervous system processes in weight regulation. However, further comprehensive examination of these regions may be necessary to confirm our findings and elucidate for possible genetic differences in different populations.
