ethanol concentrations appear to modulate glutamatergic signaling within the hippocampus as well and may have various molecular targets depending on cell type or region involved. Importantly, 30–40mM concentrations of ethanol are likely ideal for studying physiologically relevant hippocampal mechanisms of ethanol intoxication in both rodent and primate models. However, further work is necessary to determine if certain contextual or prior ethanol experience can promote hippocampal plasticity favoring alternate responses to acute ethanol exposure.
