This study was designed to assess factors deemed to be essential to the engagement of African Americans in health-related research that involves gene testing. More specifically, the study was designed to assess the influence of knowledge about genetics; beliefs regarding benefits and risks of gene testing; perceptions regarding the utility of genetic testing; and the involvement of health care providers on decisions regarding participation in health-related genetic research. The results of this study support hypotheses proposed in the organizing framework relative to influence of knowledge about genetics; beliefs regarding benefits and risks of gene testing; perceptions regarding the utility of genetic testing; and the involvement of health care providers on decisions relative to participation in health-related genetics research and the willingness to engage in health-related genetic research. As hypothesized, study findings revealed that knowledge about genetic research, perceptions regarding the utility of genetic testing, beliefs regarding the benefits and risks of genetic testing, and previous involvement in research are associated with participant's willingness to engage in health-related genetic research. Study participants reporting higher levels of trust and engagement with providers
