This study provided the first GWS evidence to our knowledge for SNPs associated with CAD via GWAS in 3 distinct genomic locations. These findings will lead our understanding of genetic vulnerability to CAD in new directions that can inform our understanding of the biology of CAD. We obtained entirely novel evidence of genetic overlap between CAD and MDD and conclude that CSMD1 may be a candidate gene that affects the risk for CAD and SCZ, a topic of considerable research interest.7,48–50 These results also suggest that common pathways (nervous system development, inflammation, and ion homeostasis) mediate the risk for multiple psychiatric disorders and dependence on multiple substances, including cannabis.
