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Chunk #43 — Materials and methods — Acoustic startle and prepulse inhibition

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Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
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Prepulse inhibition was assessed as a classic measure of reflexive whole-body information processing and movement (startle response), and sensory motor gating that occurs in response to a sudden, unexpected noise. Prepulse inhibition occurs when a softer sound (the prepulse) precedes a louder sound (acoustic startle) leading to a blunted startle response in the individual.