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Chunk #22 — 2. Materials and Methods — 2.2 Identification of mouse phenotypes and QTLs

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A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.
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to reinforcement obtains from the participation of brain dopaminergic systems, particular corticolimbic pathways, in both reward and motor stimulation. For a discussion of genetic contributions to the stimulant effects, see Phillips (1997). There are numerous QTL reported for ethanol-stimulated activity, but they are quite complex (e.g., different time windows after injection yield different signals); thus, these were not included in the present analyses.