Other phenotypes for which BXD QTL data exists were not utilized in the present set of analyses for a number of reasons. Although there are robust human data for sites in the genome associated with a low level of response to alcohol (see Wilhelmsen et al., 2003; Schuckit et al., 2005), a mouse phenotype that was a plausible surrogate was not readily available. Mice (or rats) will lose the ability to right themselves after an anesthetic dose of ethanol, and the duration of this response has been the subject of selective breeding with mice (McClearn and Kakihana, 1981) and rats. Several QTLs for this trait have been identified, but it is not clear what the appropriate human phenotype that is analogous to this trait might be.
