For phenotypes and QTLs that met the criteria stated above, published LOD plots and established maximal QTL confidence intervals with translating markers were used in the QTL studies to compare current physical map builds of human (NCBI 36 assembly of the human genome, November 2005) and mouse (NCBI m37 mouse assembly, April 2007, B6 strain) using both NCBI comparative maps (www.ncbi.nlm.nih.gov/projects/homology/maps) and Ensembl synteny maps (www.ensembl.org). Using comparative maps at NCBI, syntenic regions between mouse and human anchored by one species were identified. Anchoring to a mouse QTL, the maximal mouse chromosomal region that showed association with phenotypic scores (based upon LOD results) was determined and the syntenic human chromosomal regions identified. Then overlap of these human syntenic regions with the published human QTL regions was scanned for the respective phenotypes. Similarly, we also anchored with human QTLs and looked at the mouse syntenic regions for overlaps with published mouse QTL regions.
