Latinos in the US are a diverse group of people from many countries with varying citizenship, residency, and degree of genetic admixture. Our participants were Mexican-American men and women who were primarily US-born and living in the Fresno, CA area. This limits the generalizability of our findings to similar Latino subgroups and geographic locations. Nevertheless, the information we learned from this study could help researchers to design and develop recruitment and retention efforts for more inclusive studies that can capitalize on the richness in genetic ancestry of Latinos. Below we suggest a number of guiding questions for researchers to consider, the responses to which should be tailored to the specific population under study.