We will operationalize similar analyses for other disorders (e.g., autism with/without intellectual disability, bipolar disorder with/without psychosis or with/without lithium response). Given sex differences in disease prevalence for many disorders, analyses of genetic correlations by sex will be conducted as well. In addition, many of these disorders have significant genetic correlations with cognition, personality, and body mass. Are these genetic correlations putatively causal or due to some other process (confounding or bias)? Differences between disorders will be investigated—for example, body mass has a positive genetic correlation with MDD but a negative genetic correlation with anorexia nervosa (50).
