PPARα receptor function regulates the rate and route of HGP in the fasted state by controlling the flux of lactate and glycerol to glucose (Figure 2). Although not all studies are in agreement, a dual block in the early steps of the conversion of lactate to glucose and glycerol to glucose in PPARα −/− mice causes a maladaptation to fasting and may at least partly explain the development of hypoglycemia in these mice.
