Supportive results were also obtained using a different dataset of 265 cell types in the mouse central and peripheral nervous system18. Very strong enrichments were again seen for genes expressed in excitatory glutamatergic neurons of the cortex (especially the deep layers) and hippocampus but also the amygdala (Supplementary Figure 3). Highly significant enrichments were also seen for other neuronal populations, including as above, inhibitory medium spiny neurones in striatum, but also both excitatory and inhibitory neurons from the midbrain, thalamus and hindbrain, and inhibitory cells from the hippocampus. There was little evidence for enrichment of genes with highly specific expression in glia or microglia. Overall, the findings across all the datasets are consistent with the hypothesis that schizophrenia is primarily a disorder of neuronal function, but do not suggest that pathology is restricted to a circumscribed brain region.
