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Chunk #1 — Sensation Seeking as Intermediate Phenotype Linking Genetic Influences to Alcohol Use

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The associations between polygenic risk, sensation seeking, social support, and alcohol use in adulthood.
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showed substantial overlap in the genetic etiology between sensation seeking and alcohol use outcomes (Mustanski et al., 2003; Slutske et al., 2002). Finally, high sensation seeking is robustly associated with alcohol use among adolescents and adults (Hittner & Swickert, 2006), with some longitudinal studies suggesting that sensation seeking may be a predictor of increase alcohol use. For example, using longitudinal data from the National Longitudinal Survey of Youth, Quinn and Harden (2013) found that a slower decline in sensation seeking was associated with more rapid increase in alcohol use from ages 15 to 26.