Analysis of the most excitable cells of control, LR and NR neurons Since the most obvious phenotype for both LR and NR neurons is their hyperexcitability, we characterized the most excitable neurons in each group and compared their electrophysiological profiles. We characterized a subset of the data of neurons that had at least 35 evoked action potentials (termed ‘hyper’) in all depolarization steps in 400 ms recording (see Materials and Methods) and compared it with the remaining part of the data (termed ‘hypo’). In the control group, there were 34 ‘hyper’ of the 190 cells (18%), with an average of 58.3 ± 4.2 action potentials (compared with 11.6 ± 0.7 in the control hypo P<0.0001), whereas for the LR neurons there were 60 ‘hyper’ of the 155 cells (39%), with an average of 79.9 ± 7 action potentials (compared with 10.7 ± 1 in the LR ‘hypo’ P<0.0001), and 37 ‘hyper’ of the 112 of the NR neurons (33%), with an average of 106.8 ± 10.5 action potentials (compared with 10.1 ± 1.1 P<0.0001) (Figure 5a compares the ‘hyper’ vs
