10.7 ± 1 in the LR ‘hypo’ P<0.0001), and 37 ‘hyper’ of the 112 of the NR neurons (33%), with an average of 106.8 ± 10.5 action potentials (compared with 10.1 ± 1.1 P<0.0001) (Figure 5a compares the ‘hyper’ vs ‘hypo’ neurons in each of the three groups; Supplementary Figure 2a makes two comparisons: the ‘hyper’ neurons of each of the three groups and the ‘hypo’ neurons of each of the three groups). Sodium currents were higher in all the groups in the ‘hyper’ vs ‘hypo’ groups (at the maximum current, control increased by 85% P<0.0001, LR increased by 96% P<0.0001, NR increased by 112% P = 0.0004). The NR neurons had the lowest sodium currents in all the hyper and hypo groups (Figure 5b). The fast potassium currents were increased between control ‘hyper’ and ‘hypo’ neurons by ~ 15% (P = 0.015, two-way analysis of variance; Figure 5c). In LR, the increase was ~ 10% (P = 0.006). For the NR neurons, there was no significant increase in the fast AHP. The changes in the slow potassium currents between the ‘hyper’ groups and the ‘hypo’ groups are shown in Figure 5d. There was no significant change between any of
