the NR neurons, there was no significant increase in the fast AHP. The changes in the slow potassium currents between the ‘hyper’ groups and the ‘hypo’ groups are shown in Figure 5d. There was no significant change between any of the pairs. The sodium-to-potassium ratio in the ‘hyper’ vs ‘hypo’ sets of the data was larger in all groups by ~ 56% control (P<0.0001), 112% LR (P<0.0001) and 102% NR groups (P<0.0001, Figure 5e and Supplementary Figure 2b). Another interesting phenomenon (Figure 5e and Supplementary Figure 2b) was that there were both ‘hyper’ LR and NR neurons with a ratio of sodium-to potassium close to 0 (but not the controls), indicating that BD neurons can be hyperexcitable even with very low sodium-to-potassium ratio. The capacitance was larger in the ‘hyper’ groups of the control and LR (59% control, P<0.0001 and 24% LR, P = 0.0002), confirming a reduced correlation between capacitance and excitability in NR neurons (Figure 5f and Supplementary Figure 2c). The input conductance of the neurons generally did not change between the ‘hyper’ groups and ‘hypo’ groups (an increase of 40% in the control ‘hyper’ vs ‘hypo’ cells, P = 0.05, Figure 5g and Supplementary Figure 2d).
