limited number of higher-burden measures may be included.Working groups should select measures that are expected to be relevant for at least the next few years.Working groups are encouraged to select protocols that are broadly applicable to a variety of populations. A single PhenX measure may have multiple context-dependent protocols to accommodate life-stage and gender variations. The working groups recognize and discuss the potential for cultural differences’ affecting the measures and take that into consideration when selecting specific protocols.Although the primary focus of PhenX is research in US populations, international measures and standards may also be considered. Scientists from other countries are encouraged to use the PhenX Toolkit.