Therefore, this paper evaluated the relations between LR and other related risk factors (FH of AUDs, the age of drinking onset, prior drinking quantities, age, and body mass index) on the occurrence of AUDs across adulthood using discrete-time survival analysis (DTSA) with probands from the ongoing San Diego Prospective Study. Our primary hypothesis was that a low LR to alcohol would relate to the occurrence of AUDs across adulthood even after controlling for other robust risk factors for AUDs. We also expected that a positive FH of AUDs, early drinking onset, and higher levels of baseline drinking would all predict AUD occurrence. Furthermore, we proposed several interactions among the risk factors for AUDs including: an enhanced association for all risk factors on AUDs within FHP subjects, reflecting the fact that risk for AUDs is heterogeneous and FHP subjects with additional risk factors would be at increased risk for heavier drinking and AUDs in adulthood (Schuckit, 2009); higher levels of baseline typical quantity of alcohol use would facilitate and amplify the impact of other risk factors on AUDs by creating an
