The goal of this study is to evaluate substance use in individuals with chronic psychotic disorders (cases) as compared to population controls. With the 5 measures listed above as independent variables, we used logistic regression to model the probability of substance use based on case/control status, adjusted for race & ethnicity, gender, age (< age 30, age 30-49, or ≥ age 50), and recruitment site. We also evaluated whether there are significant interactions on substance use between case control status and race & ethnicity, gender, or age. All analyses were performed using SAS 9.2 for Windows30.