The identification of genetic variants that confer risk of a diverse set of psychiatric disorders parallels findings from other medical specialties. Most notably, GWAS41,42 of autoimmune disorders have shown extensive overlap in genetic variants that affect a diverse range of diseases, including rheumatoid arthritis, coeliac disease, multiple sclerosis, systemic lupus erythematosus, psoriasis, Crohn’s disease, and type 1 diabetes. Our results provide insights into the shared causation of psychiatric dis orders (panel). In particular, alterations in calcium-channel signalling could represent a fundamental mechanism contributing to a broad vulnerability to psychopathology.
