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Chunk #24 — Results — Functional annotation analysis of genes affected by prenatal alcohol exposure

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Prenatal alcohol exposure alters expression of neurogenesis-related genes in an ex vivo cell culture model.
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The validity of the microarray results was confirmed with selected genes from each data set chosen based on genes on either large positive or negative fold changes or highly significant p values. Real-time results of selected genes are shown in Table 3. For the proliferating culture conditions, decreased expression of Adora2a (p = .05), Hes1 (p = .01), Vegfa (p = .01), and increased expression of Sox3 (p = .02) were confirmed. For differentiated culture conditions, the reduced expression of Gdnf (p = .04) and Hey2 (p = .01) were also confirmed.