blood vessel development, proliferation, and organization of the cytoskeleton, all with p <.001 as seen in Table 1. These categories mostly include Adora2a and Vegfa. Functional annotations for genes altered under differentiated conditions include survival of neurons; differentiation of NPCs, neurons, and cells; neurogenesis; and proliferation of microglia, all with p <.001 as seen in Table 2. These categories are likely predominantly driven by the alterations in Gdnf and Hey2.