A principal goal of this research was to identify particularly efficacious smoking cessation pharmacotherapy interventions amongst the five different treatments tested in a head-to-head comparison. The nicotine patch + lozenge combination emerged as the treatment with the strongest support. Its odds ratio at 6-months postquit was 2.34, while the next highest odds ratio was 1.83 (for the nicotine patch). The nicotine patch + lozenge combination emerged as the only efficacious treatment (after Bonferroni correction for multiple tests), relative to placebo, at 6-months post-quit. In addition, relative to a monotherapy composite, the patch + lozenge condition produced higher initial cessation rates and end-of-treatment 7-day point-prevalence rates using the Bonferroni-corrected alpha level. The patch + lozenge combination also tended to produce more positive outcomes than any other condition, active or placebo, on measures such as days to lapse and days to relapse (see Figure 3); these differences did not exceed protection levels for multiple comparisons, however. These effects are consistent with previous research showing that the patch + ad lib NRT increases the time to relapse.25 Finally, while there was substantial evidence
