Just in the past two years, genotype imputation based analyses have become a key tool for the analysis of human genetic data. They have been used to aid fine-mapping studies, to increase the power of genome wide association studies, to extract maximum value from existing family samples, and to facilitate meta-analysis of genomewide association data. In the next few years, we expect these imputation based analysis will become a key tool in the analysis of massively parallel shotgun sequence data, enabling geneticists to rapidly deploy these technologies to analyze large samples and dissect the genetic basis of complex disease.
