All RNA-seq samples profiled in this study were also profiled in the FANTOM5 promoterome manuscript and are described in detail there 6. Briefly all human samples used in the project were either exempted material (available in public collections or commercially available), or provided under informed consent. All non-exempt material is covered under RIKEN Yokohama Ethics applications (H17-34 and H21-14). For the samples profiled by RNA-seq, the human fetal heart RNA was purchased from Clontech (Cat no.636583). CD19+ B-cells and CD8+ T-cells were isolated using the pluriBead®system (huCD4/CD8 cascade and huCD19 single; PluriSelect). RNA was then extracted using the miRNeasy kit (Qiagen).
