Chunk #80 — PART II. CORE QUESTIONS — F. What is the Content of those Responsibilities? Four Issues and Who Should Address Them — Step 1: Clarifying the criteria and roster
Moreover, most efforts that have been suggested and are being piloted to assemble a roster of returnable results in genetic and genomic research have focused only on genetic and genomic results.101 Yet IFs and IRRs generated by biobank and secondary research will be broader and include non-genetic findings. IFs uncovered in ascertaining the suitability of an individual for participation in the biobank research and in baseline screening are likely to be non-genetic.102 Thus, the website for UK Biobank promises return of enrollment and baseline screening IFs such as elevated blood pressure.22,23 Even after biobank research itself has begun, biobanks and secondary researchers may well find non-genetic IFs, such as discrepant diagnosis when tumor specimens are reanalyzed at the biobank24, or unrecognized phenotypic findings of significance in the electronic medical records, when those records are linked to genetic analyses for the purposes of research, as at eMERGE sites.9 Further, some biobanks are linking genetic and non-genetic data, such as neuroimaging scans, to look for connections between individuals’ genetic make-up and brain abnormalities;103,104 such linked databases have potential to generate non-genetic IFs
