The effect of clonidine 40 µg/kg treatment on intake of saccharin solution during 2-h trials on each of 3 consecutive days is presented in Fig. 5. There was no significant difference in pre-drug saccharin intake among treatment groups. During the 3 treatment days there was a significant effect of clonidine treatment [F(1,18) = 12.97, p < 0.01] and a significant effect of day [F(2,36) = 3.97, p < 0.05] on saccharin intake, but no significant treatment × day interaction. Pairwise comparisons using the Fisher’s LSD test revealed that saccharin intake was decreased (p < 0.01) independent of day by clonidine treatment relative to treatment with saline vehicle.
