In this study we investigated main effects of the CRHBP gene and G × E interactive effects on suicidal behavior in a sample of African American participants with substance dependence. We did indeed find nominally significant G × E effects for CRHBP SNPs rs7728378, rs10474485 and rs6453267 although after FDR correction only the results for rs7728378 remained significant. Other than rs6453267, which has a protective allele that is common in African Americans but is rare or absent in other ethnic groups, we did not detect any main effects of CRHBP variation on suicide risk.
