The CRHBP SNPs rs7728378 and rs10474485 that were implicated in suicidal behavior showed significant or trend associations with anxiety disorders in Plains Indians and AUDs in U.S. Caucasians and were included in one distal haplotype block in these two samples (Enoch et al., 2008). The SNP rs7728378 that showed the strongest effect in our earlier study also showed the strongest interactive effect with childhood trauma in our current study. It is also noteworthy that the same rs7728378 allele was implicated in suicidal behavior in the African Americans and AUD in the U.S. Caucasians however the allele frequencies were very different: 0.77 in African Americans and 0.38 in U.S. Caucasians. The results from four other CRHBP studies (see Fig. 3) also lend support to our findings. In a study of schizophrenics, rs1875999 heterozygotes had a greater risk of attempting suicide (De Luca et al., 2010). Rs10474485 was associated with remission of depressive symptoms, predominantly in individuals with anxious depression (Binder et al., 2010) and with depressive symptoms in alcoholics in a study that genotyped the same SNPs as in the current
