Chunk #31 — Methods and results — Testing for significance of gene-environment interaction effects using the reparameterized equation

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Testing for measured gene-environment interaction: problems with the use of cross-product terms and a regression model reparameterization solution.

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First we rewrite Eq. (3) for each of the three genotype groups: whenG=0,P∣(G=0)=γ0+γ2E,whenG=1,P∣(G=1)=(γ0+γ1+γ4)+(γ2+γ3+γ5)E,whenG=2,P∣(G=2)=(γ0+2γ1+4γ4)+(γ2+2γ3+4γ5)E.