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Chunk #72 — Methods — Unsupervised learning to determine TUD clustering.

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.
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The product of HCA is a dendrogram, formed with multiple brackets called “branches”. Phenotypes on the same branch are more similar to each other based on their pairwise genetic associations with each other and with all other phenotypes on that branch. Branches can form subbranches of more specific clustering. The genetic correlations of Former Smoker and Smoking Initiation were reversed to show the intuitive effects against the other traits in the dendrogram.