We performed a PheWAS in the Mayo Clinic Biobank (MCB).107 Phecodes were ascertained using EHR data from 57,001 patients from the Mayo Clinic Biobank. Genotyping details are included in the Supplementary Materials. PGS were calculated using LDpred2108 using the auto feature in the bigsnpr (v1.10.4) R package. To evaluate the unique contribution of polygenic scores for TUD in relation to other smoking behaviors, we calculated PGS for SmkInit, CPD13 and FTND27 and ran additional PheWAS of TUD covarying for SmkInit, CPD and FTND PGS.
