quality, by developing and refining data entry SOPs, improving training and expanding the number of curators. These updates and enhancements will be described in more detail under the following four headings: (i) Frontend Layout, Backend and Curation Protocols; (ii) Data Additions; (iii) Data Quality Enhancements and (iv) Interface Improvements. Overall, we believe these advancements will ensure DrugBank remains a vital data resource in a landscape that is increasingly reliant on data-driven, in silico approaches.