iii. Genes enriched in BP vs control neurons Of the 1312 unique transcripts that were altered in neurons, 140 transcripts were increased 1.5-fold or greater in BP, including transcripts associated with cell–cell and/or cell–matrix interactions and with axon outgrowth, with neuronal differentiation, organization of synapses, secreted growth factors, and neurotransmitters and their receptors. Many membrane-associated channel genes, transcripts involved in methylation and control of gene expression and with the cytoskeleton were also increased in BP neurons. Functional Annotation Cluster Analysis identified plasma membrane part and ion transport as significantly increased in BP neurons (Table 4iii). Both clusters (Supplementary Tables 8 and 9) contained transcripts previously associated with neurodevelopmental/neuropsychiatric disorders, as well as BP susceptibility loci.
