We genotyped nine SNPs in the 3’ NRXN3 regions that lie near two splicing sites, termed SS#4 and SS#5, in 144 European-American alcohol dependent and 188 control individuals from Sample 3 [130]. Minor allele frequencies at four SNPs near SS#5 were each higher in alcohol dependent than in control samples, supporting initial observations in other samples. A “T” allele at the rs8019381 (close to the original rs760288 SNP) produced a 2.46 odds ratio for belonging to the alcohol dependent group. Common 3 SNP haplotypes in this area were also strongly associated with alcohol dependence (nominal p= 0.000598, corrected to p= 0.00580 based on permutations).
