Maternal substance use during pregnancy data were analyzed with Pearson chi-square (categorical variables) or linear mixed models (continuous variables) (Table 2). Maternal report occurred at an average of 12.27 years postpartum. Mothers with a family history of SUD were significantly more likely to use any substance (alcohol, cigarettes, and/or drugs) during pregnancy than LR control mothers (χ2=59.89, p<.001). The HR mothers consumed more alcohol (χ2=33.90, p<.001), cigarettes (χ2=53.41, p<.001), and other drugs (χ2=35.64, p<.001) than mothers from LR families (Figure 2). Among women who used substances during pregnancy, HR mothers reported consuming greater amounts of alcohol (F(1,79)=6.28, p=.014) and cigarettes (F(1,77)=4.54, p=.036) over the course of pregnancy than LR mothers. High-risk mothers who drank during pregnancy consumed an average of 6.03 drinks per week across pregnancy, compared to an average of 0.56 drinks per week among low-risk mothers. High-risk mothers who smoked cigarettes during pregnancy consumed an average of 4.35 packs per week across pregnancy, compared to an average of 2.34 packs per week among low-risk mothers. Because only one LR mother used other drugs during pregnancy, we were unable to compare the number of days of drug use between risk groups.
