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Chunk #8 — Materials and Methods — Population-based samples — ALSPAC

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Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples.
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The Avon Longitudinal Study of Parents and Children (ALSPAC) sample (Golding et al., 2001; Boyd et al., 2013) includes children born in Avon, UK in 1991-1992. ALSPAC recruited a total of 15,458 children from a birth cohort of 15,247 pregnancies, most of whom have been followed longitudinally since birth and assessed at multiple waves. Please note that the study website contains details of all the data that is available through a fully searchable data dictionary at http://www.bris.ac.uk/alspac/researchers/data-access/data-dictionary. The present study uses data from the follow-up assessment at age 18 (M = 17.9, range = 16.3 – 20.0), which included an in-person, computer-assisted clinic assessment of alcohol problems, supplemented by imputed data from a similar assessment at age 16.5 for those with missing data (Edwards et al., 2015). Included in the present study were 4,304 individuals (57.0% female) of European ancestry who had both phenotypic and genotypic data available for analysis.