Importantly, to compute the dichotomous and density measures of FH using COGA family data, we applied two inclusion criteria. 1) The subject and at least one of their family members had to have DSM-5 AUD symptom count and diagnostic information. 2) The diagnostic information must be assessed using only direct interviews. That is, only those subjects and their relatives, whose affectedness information was gathered through the administration of the SSAGA were used for the analyses in this study. A total of 16,346 subjects (Mage=37.24; SD=15.00) from 1,934 families, each of which comprised between 2 and 84 family members (MFamMem=15.51; SD=13.80) fulfilled these criteria (see Table 1 for details on sample characteristics). The kinship information among family members was self-reported by participants and cross-verified through other family members. That is, at the time of their assessment/direct interview, participants described their family members and the relationships among them, and when their family members were assessed/directly interviewed, they in turn verified these relationships.
