In comparison with EA_H1, although EA_H4 was physically encompassed by EA_H1, and they share 1 SNP (i.e., rs16969968), EA_H2 and EA_H3, which have 2 overlapping SNPs (i.e., rs3743075 and rs8040868), were physically separate from EA_H1. Also in the MSTF cohort, we detected two AA haplotypes formed by rs1317286-rs12914385-rs2869546 (AA_H1) and rs2869546-rs6495308-rs3743075 (AA_H2), which share 1 SNP (i.e., rs2869546) (Figure 3). Comparing the detected haplotypes in AAs and EAs, AA_H1 does not physically overlap with any of the 4 EA haplotypes, and AA_H2 shares 2 SNPs (i.e., rs6495308 and rs3743075) with EA_H2, as well as 1 SNP (i.e., rs3743075) with EA_H3. Although the overall physical region spanned by the 9 overlapping Korean haplotypes identified in this study from rs16969948 to rs6495316 does encompass all 4 EA haplotypes (i.e., EA_H1, EA_H2, EA_H3, and EA_H4) as well as both AA haplotypes (i.e., AA_H1 and AA_H2), these 9 Korean haplotypes do not share any SNPs with EA_H1 EA_H3, EA_H4 or AA_H1. Nevertheless, 3 Korean haplotypes (Korean_H3, Korean_H4, and Korean_H5) do share an SNP (i.e., rs6495308) with EA_H2 and AA_H2. Overall, the Korean haplotypes provide some support for the importance of the EA and AA haplotypes previously associated with smoking-related phenotypes However, because the SNP
