Chunk #42 — METHODS — Association analyses.

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Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.

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effect of SNPs associated with PTSD phenotypes, we analyzed top SNPs (at suggestive threshold P < 5 × 10−6) for their unique and overlapping distribution across the five phenotypes. The top SNPs for each phenotype were LD pruned (r2 = 0.2, kb = 250) to obtain independent signals and investigated for their role as quantitative trait loci for protein expression, DNA methylation, and splicing (brain tissues) from the QTLbase29.