adjustment. We used GEAR rather than GCTA to estimate heritability since the PC-Relate kinship matrix estimate was not positive definite; this can be explained by the fact that the matrix entries are computed based on different allele frequencies, i.e., those depending on ancestry from the PC analysis. In all analyses we removed individuals so that no two remaining individuals had a kinship estimate >0.025; sample size was maximized with Plink v1.959, leaving us with 62,133 individuals.
