Glycogen Synthesis in Red Muscle, R gly. Net glycogen mass and synthesis (R gly), obtained by averaging red gastrocnemius and red quadriceps muscle data, are summarized in Table 6. R gly was close to zero in all groups in the basal fasting state. Tesaglitazar succeeded in completely normalizing the insulin induced increase in R gly. Comparison of the magnitudes of R g′ (reflecting the sum of glycolysis and glycogen synthesis) and R gly suggests that the insulin induced increases in R g′ in Lean and Tesaglitazar groups involved increases in both glycolysis and glycogen synthesis. In the basal state, tesaglitazar reduced glycogen mass to the levels seen in lean animals (Table 7).
