Glucose Utilization by Individual Tissues, R g′. Overall the R g′ results (left column, Figure 4) generally agree with Basal and ClampL results from Study 2 consistent with tesaglitazar induced amelioration of insulin resistance in key insulin target tissues. Moderate differences in absolute R g′ levels between the two studies may have been the result of the different methodologies used to assess tissue 2DG tracer retention (see Section 2) with a potentially more accurate method used in the current study. Note that hepatic R g′ data is not represented in Figure 4 as the estimates are not valid due to poor metabolic trapping of 2DG in this tissue [25].
