Tissue Specific Nonoxidative FFA Disposal, R fs. While R f* indexes uptake into both oxidative and nonoxidative disposal, the parameter R fs (summarized in Table 6) represents flux into nonoxidative disposal only. Generally the between group pattern described previously for R f* was also seen for R fs with these two variables strongly positively correlated (data not shown). In the basal state, tesaglitazar normalized R fs in the heart only with no apparent normalization of the elevated levels in other tissues including skeletal muscle and liver (which in fact was further increased by treatment). This latter result was particularly surprising to us due to the established influence of PPARα stimulation in upregulating β-oxidation machinery. Tesaglitazar greatly improved insulin's ability to suppress tissue nonoxidative FFA disposal resulting in normalization of R fs at physiological hyperinsulinemia in all tissues examined.
