Tissue Specific FFA Clearance, K f*. K f* is a measure of the local ability of the tissues to utilize FFA. While FFA level was clearly a dominant factor in determining between group differences in R f* of an individual tissue, the K f* data (right most column, Figure 4) revealed insulin mediated regulation/dysregulation of FFA utilization at the local tissue level. Thus in Lean tissues, insulin exerted heterogeneous effects on K f* which were lost in the Obese tissues: stimulation in skeletal muscle and suppression in heart and liver with no significant effect in white fat or cerebellum. Surprisingly, tesaglitazar did not induce normalization of the response to insulin in this parameter in any of the tissues examined. In white fat tesaglitazar induced an increase in K f* which was potentiated by insulin (Figure 4).
