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Chunk #16 — Results — Selection Study

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Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.
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Although we did not find high linkage disequilibrium in this region overall, for a core region spanning these three additional markers in EAs we found higher Relative Extended Haplotype Homozygosity (high LD extending from a high frequency haplotype – a departure from neutrality) for the three-derived-allele haplotype than for the three-ancestral-allele haplotype. In AAs, we found the opposite effect.