The third relatively consistent predictor of alcohol remission was the low LR to alcohol which contributed as a trend for initial remission and was a significant predictor for sustained remission. This endophenotype is one of several genetically-influenced characteristics observed early in life that predict later AUDs, and has a modest effect size (Schuckit, 2009b). Compared to some other endophenotypes (e.g., impulsivity), the low LR is not as closely associated with the development of multiple substance use disorders or major psychiatric symptoms later in life. While LR significantly predicted the development of an AUD, it may not be as closely associated with high levels of life problems and lower life stability outside the alcohol domain, and such comorbidities are associated with a worse prognosis among alcoholics (Crum et al., 2008; Hasin et al., 1996). Thus, an individual who develops an AUD in the context of a low LR might be less likely to have interpersonal, social, and personality characteristics that interfere with the recognition that a problem exists and might demonstrate a greater ability to address life problems associated with heavy drinking.
