Consistent with this interpretation, it is noteworthy that the relative reductions in GAD67 and CB1R mRNA expression in the mPFC of GAD67+/− mice are similar to those observed in schizophrenia; mean GAD67 and CB1R mRNA levels are significantly ~28–37% (18,19) and 15% (6) lower, respectively, in the DLPFC of subjects with schizophrenia. In addition, the GAD67+/− mice have lower GAD67 expression across the cortical mantle, consistent with the observations that GAD67 mRNA levels are lower to a similar degree in multiple cortical regions in the same subjects with schizophrenia (19). However, GAD67 mRNA expression is reduced from early prenatal life in the GAD67+/− mice and whether this time course matches that of the GAD67 mRNA deficit in schizophrenia is unknown.
